Liquisolid Technique : A Novel Approach For Enhancement of Solubility and Bioavailability
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چکیده
منابع مشابه
Solubility Enhancement of Carvedilol Using Liquisolid Compact Technique
A novel liquisolid compact technique was used for soulbility enahncement of poorly water soluble drug carvedilol (CAR). CAR was dissolved in water miscible non volatile solvent and then adsorbed on a solid carrier which was later compacted with other excipient into a tablet. The tablets were characterized with respect to hardness, friability, disintegration and in-vitro dissolution profile. Eff...
متن کاملFormulation and Evaluation of Immediate Release Tablet of Carvedilol using Liquisolid Compacts Technique for Solubility Enhancement
Aim: The aim of this study was to formulate and evaluate liquisolid compact system of carvedilol to give increased dissolution rate of drug by utilizing PEG400 as the non-volatile liquid vehicle. Materials and Methods: The liquisolid tablets formulated with PEG400 at different concentrations. The suitable analytical method based on UV-visible spectrophotometer was developed for carvedilol. Resu...
متن کاملLiquisolid Technique for Enhancement of Dissolution Properties of Fenofibrate
The in vitro dissolution property of slightly water soluble Fenofibrate (FN) was improved by exploring the potential of Liquisolid system (LS). The in vitro release pattern of LS compacts and directly compressed tablets were studied using USP-II apparatus. Different LS compacts were prepared using a mathematical model to calculate the required quantities of powder and liquid ingredients to prod...
متن کاملEnhancement of Dissolution Properties of Amlodipine Besylate Using Liquisolid Technique
The most promising method for enhancing solubility, therefore promoting the rate of dissolution is the formation of liquisolid compacts.[2]With Liquisolid technique as described by Spireas liquid formulations such as solutions or suspensions of poorly soluble drugs in a non-volatile liquid vehicle are converted into acceptably flowing and compressible powders, by simple physical blending with s...
متن کاملLiquisolid Dosage System: A Novel Approach for Dosage formulation
Liquisolid system is a novel concept of dosage formulation for water insoluble drugs and lipophilic drugs via oral route. Formulation concept of liquisolid technology involves water insoluble drugs dissolved in suitable non-volatile liquid vehicles, and converted in to compact by blending with selective powder excipients. Liquisolid compacts are compressible powdered forms of liquid medications...
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ژورنال
عنوان ژورنال: American Journal of Pharmacy And Health Research
سال: 2018
ISSN: 2321-3647
DOI: 10.46624/ajphr.2018.v6.i3.002